Isabel won't actually say 'Hey, do you think that's a bad idea?' Especially since she's absolutely positive he'd blow her off anyway. He wants to get away from civilization (and, okay, her too), and won't take no for an answer. Not even from his familiar.

Which kind of blows, because he ought to know that Califleur, at least, has his best interests in mind.

So instead of calling after him, she gives Chaos an expressive look--at which the Maine Coon gives her a resigned mrrp, and they just both try to make it seem casual, as they follow along after Kuja and his leopard.